Precision medicine has the potential to transform the future medical practice. For most mental disorders, currently there has been no precise biological tests or effective treatments. Success of precision medicine in psychiatry depends on our understanding of individual genetic makeup, symptoms, cognitive assessment, and environmental exposures. Recent breakthroughs in genome-wide association studies (GWAS) and large-scale sequencing projects in psychiatry yield hundreds of genetic risk loci, bringing forth enormous opportunities but also posting challenges for translating genetic findings into accurate disease biology and clinical interventions. A likely paradigm change of psychiatric genetic architecture from polygenic to omnigenic model as well as pleiotropy nature further amplify such challenges. A multidiscipline approach that can integrate data at multiple levels (e.g., genomics, molecular, cellular, physiological, brain imaging and other phenotypes) is highly needed. Moreover, it is also instrumental to embrace novel technologies for data collection (e.g., using mobile platform). This workshop covers a variety of topics related to psychiatry, ranging from smartphone-based omics profiling and phenotype collection in mental disorders, schizophrenia genetics, braining imaging, functional genomics and patient-specific induced pluripotent stem cell (iPSC) disease modeling. The main goals of the workshop are: to inform Chinese basic and clinical researchers in mental health about the forefront research approaches and progress on psychiatric genetics, genomics, disease modeling and phenotyping in the context of psychiatric precision medicine; to promote research collaboration and resource sharing between US and Chinese researchers in mental health.
Organizers:
Jubao Duan, Ph.D.
Director, Unit of Functional Genomics in Psychiatry, NorthShore University HealthSystem
Assistant Professor, Department of Psychiatry and Behavioral Neuroscience, University of Chicago
Weihua Yue, M.D.
Professor and Deputy Director of Institute of Mental Health, Sixth Hospital, Peking University
Sponsors:
The Peking University Sixth Hospital
The University of Chicago Beijing Center
Introduction of US Speakers:
1. Pablo V. Gejman, MD. Dr. Gejman is the Vice President of Genomics, Director of Genomics Health Initiative (GHI) and Director of Center for Psychiatric Genetics (CPG) at NorthShore University HealthSystem. He is a Professor of the Department of Psychiatry and Behavioral Neuroscience at the University of Chicago. He is a world-renowned psychiatric geneticist. He led the phase I schizophrenia GWAS of Psychiatric Genomics Consortium (PGC), resulting in publications in Nature and Nature Genetics. He is currently leading the NIH-funded Illinois Precision Medicine Initiative (PMI) at NorthShore consortium site. Dr. Gejman will discuss new developments in precision medicine and their implications for Psychiatry. He will focus on translation of clinical genomics research findings into medical applications that can be implemented by general practitioners. Dr. Gejman will also provide an overview of research initiatives at the Genomic Health Initiative of NorthShore.
2. Daniel Fridberg, Ph.D. Dr. Fridberg is an Assistant professor in the Department of Psychiatry and Behavioral Neuroscience at the University of Chicago. Dr. Fridberg also serves as the co-director of the University of Chicago Tobacco Cessation Program where he provides group and individual psychotherapy to assist patients in quitting smoking. He is a licensed clinical psychologist and has clinical and research interests in acute alcohol and drug responses, neurocognition in addiction, brief motivational interventions, and smoking cessation in heavy drinkers. His current research, funded by the National Institute on Alcohol Abuse and Alcoholism, is focused on developing a novel method to assess alcohol responses in young adult heavy drinkers using smartphones. He will present his NIH-funded alcohol research project involving the application of mobile technology in collecting phenotype data.
3. Jubao Duan, Ph.D. Dr. Duan is the Director of the Unit of Functional Genomics in Psychiatry at NorthShore University Healthsystem. He is an Assistant Professor of Department of Psychiatry and Behavioral Neuroscience at the University of Chicago. Dr. Duan has made seminar contributions to the field of schizophrenia genetic and genomics research over the years. Dr. Duan’s research is funded by multiple NIH grants, focusing on functional genomics of schizophrenia and other neuropsychiatric disorders in patient-specific induced pluripotent stem cell (iPSC) model. He will discuss the recent progress of schizophrenia genetics and the application of patient-specific iPSC model for translating genetic findings to disease biology and potentially to more tailored individualized treatments. Talk title: Schizophrenia genetics and disease modeling in 2D and 3D human iPSC models.
4. Chunyu Liu, Ph.D. Associate Professor of the Department of Psychiatry, University of Illinois at Chicago. The Changjiang Chair Professor at Shanxi Normal University. Dr. Liu is interested in genetics, genomics and epigenomics of psychiatric disorders and behavioral traits. His study is funded by NIH. He will present a summary of major published genome-wide association studies in psychiatry, along with some interesting findings about genotype-phenotype relationships
5. Zhiping Pang, Ph.D. Assistant professor of Neuroscience and Cell Biology at Rutgers University Robert Wood Johnson Medical School. Dr. Pang is a pioneer in direct conversion of human skin fibroblasts into functional neurons. He was the recipient of the Daniel X. Freedman Prize from Brain and Behavior Research Foundation in 2012. His main research interest is the regulation of synaptic transmission in health and disease using both mouse models and human neurons derived from stem cells. His research is mainly funded by NIH.
Schedule:
22号上午
8:40-9:00
陆林 教授
开幕致辞
陈冬雪
9:00-10:00
陆林 教授
中国精神卫生发展现状
9:50-10:10
茶歇及合影
10:10-11:00
张岱 教授
精神疾病分子遗传学研究（1）——孤独症的遗传易感基因功能研究
11:00-11:50
赵一鸣 教授
临床研究规范简介
午 休
22号下午
13:00-14:00
司天梅 教授
抑郁症诊疗的客观标记物研究
陈冬雪
14:00-15:00
马燚娜 教授
精神疾病脑影像学研究（1）——催产素功能的社会适应模型The Social Adaptation Model of Oxytocin Function
15:00-15:20
休 息
15:20-16:20
黄雨 副教授
精神疾病科研协同数据平台使用及管理
16:20-17:20
Weihua Yue, M.D.
岳伟华 教授
精神疾病分子遗传学研究（2）——Genetic variants associated with response to antipsychotics treatment in schizophrenia: a genome-wide association study
23号上午
8:00-9:00
于欣 教授
临床研究的思路与组织模式
段聚宝
岳伟华
9:00-10:00
Pablo V. Gejman, MD.
Precision Medicine Initiative and Precision Psychiatry: What can they learn from each other?（精准医学创始计划和精准精神病学：二者的相互借鉴）
10:00-10:20
休 息
10:20-11:10
Prof. Tianzi Jiang, Ph.D.
蒋田仔 教授
精神疾病脑影像学进展（2）——Brainnetome Atlas and its Application in Brain Disorders（Atlas 脑组学数据库及其在脑疾病中的应用）
11:10-12:00
Chunyu Liu, Ph.D.
刘春宇
精神疾病分子遗传学研究（3）A Bird’s Eye View of Psychiatry GWAS for Geneticists and Clinicians
午 休
23号下午
14:00-14:45
Jubao Duan, Ph.D.
段聚宝
精神疾病分子遗传学研究（4）——Schizophrenia genetics and disease modeling in 2D and 3D human iPSC models
刘春宇
14:45-15:30
Zhiping Pang
庞志平
Synaptic mechanisms of genetic variants associated with nicotine dependence and alcoholism
15:30-15:45
休 息
15:45-16:30
Li Yang, M.D.
杨莉 副教授
Bridging the gap between pathophysiology and precise medicine of ADHD（连接ADHD的病理生理学与精准医学之间的桥梁）
16:30-17:15
Daniel Fridberg, Ph.D.
A novel, smartphone-based method to measure alcohol responses in the natural environment.（一项基于智能移动设备在自然环境下评估酒精反应的新方法）
